5-Hydroxytryptophan (5-HTP): The primary active compound, a direct precursor to the neurotransmitter serotonin.

How does it work?

Serotonin Synthesis and Mood Regulation:5-HTP from Griffonia simplicifolia seeds crosses the blood-brain barrier and is converted to serotonin (5-hydroxytryptamine) by the enzyme aromatic L-amino acid decarboxylase (AAAD). Elevated serotonin levels in the brain enhance mood, focus and work performance. It alleviates mood swings, procrastination, and anxiety.

Melatonin Production and Sleep Regulation: Serotonin serves as a precursor to melatonin, a hormone that regulates sleep-wake cycles. The conversion of serotonin to melatonin occurs in the pineal gland, facilitated by the enzymes serotonin N-acetyltransferase (NAT) and hydroxyindole O-methyltransferase (HIOMT). Increased melatonin production enhances sleep quality and duration “beauty sleep”, which improves cognitive function, and longevity.

Neuroprotective Effects: 5-HTP-induced serotonin synthesis exhibits neuroprotective effects by modulating neuroinflammation, reducing oxidative stress, and promoting neuronal survival through the activation of neurotrophic factors such as brain-derived neurotrophic factor (BDNF).

Regulation of Appetite and Weight Management: Serotonin regulates appetite and satiety by acting on specific receptors in the hypothalamus, particularly the 5-HT2C receptors. Increased serotonin levels can suppress appetite and promote a feeling of fullness.

Antioxidant Properties:The antioxidant properties of 5-HTP and serotonin protect cells from oxidative damage (ROS).